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Suggestions for Control Tissues
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Suggestions for Control Tissues

Roy C. Ellis

IMVS Division of Pathology

The Queen Elizabeth Hospital

Woodville Road, Woodville, South Australia 5011

Acid phosphataseProstate, liver or kidney
Adenosine triphosphataseMuscle or liver
AdrenalineAdrenal medulla
Alkaline phosphataseKidney or small intestine
AlphafoetoproteinPrimary carcinoma of liver
AluminiumLung or skin in diseased patient
Amyloid AAWidespread but kidney, liver, spleen, lymph nodes, adrenal and thyroid are classically involved.
Amyloid ALWidespread but heart, gastro-intestinal tract, peripheral nerves, skin and tongue are classically involved.
Argentaffin cellsAppendix or ileum
ArgininePaneth cells and lymphoid tissue
Argyrophil cellsStomach, small intestine
ArsenicHair, nails and bone
Ascorbic acidLiver or adrenal cortex
AspergillusLung in diseased patient
Astrocytes, fibrousBrain white matter
Astrocytes, protoplasmicBrain grey matter
AxonsCerebrum, cerebellum, spinal cord
Basement membranesKidney
BerylliumLung in diseased patient
BilirubinBiliary cirrhosis, cholelithiasis
BiliverdinBiliary cirrhosis, cholelithiasis
CalcitoninDog thyroid
Calcium carbonateBone, necrosis, atheroma
Calcium oxalateKidney or thyroid in oxalosis, bone
Calcium phosphateBone, necrosis, atheroma
Candida albicansSkin of diseased patient
Carcino-embryonic antigenColon
CarcinoidAppendix, small intestine, rectum and sigmoid colon.
Cartilage, fibrousInvertebral discs
Cartilage, hyalineJoints
Charcot-leyden crystalsLung of asthmatics, eosinophil granulomas
ChitinHydatid cysts of liver and lung
CholesterolAdrenal cortex and atheroma
ChromaffinAdrenal medulla
CollagenSkin, lung or liver
CopperLiver in diseased patient - Wilson's disease, primary biliary cirrhosis
CryptococcusLung of diseased patient
CysteineHair follicles
CystineStratum corneum and hair shafts
Cytochrome oxidaseLiver, muscle and kidney
Degenerate myelinBrain of patients with multiple schlerosis
DehydrogenaseLiver, kidney and heart
DendritesCerebrum, cerebellum, spinal cord
DNALymph node
DopamineMast cells of mice and rats
Elastic fibresAorta, dermis of skin, lung or intestine
Epidermis, intercellularbridgesSquamous cell papilloma, palmar and plantar skin
Esterase (non specific)Liver, kidney or small intestine
Fatty acidsFat necrosis
FibrinFoetal lung in hyaline membrane disease
Ganglion cellsWalls of the gastro-intestinal tract
Golgi apparatusNeurones
Gram negative organismsControls can be manufactured using a culture from a known organism and lung from autopsy. Culture together for 24 hours then fix and process.
Gram positive organismsAs for gram negative organisms
HaematoidinInfarcts and abscesses
HaemazoinLiver of malaria patients
HaemosiderinHaemorrhage and haemochromotosis
Hepatitis B surface antigenLiver in viral hepatitis
Human chorionicPlacenta gonadotrophin
Hyaluronic acidUmbilical cord
IronLiver in hemochromatosis
KeratinPalmar and plantar skin
Legionella pneumophiliaLung of diseased patient
Leprosy bacilli (myco leprae)Skin of diseased patient
LipidCorpus luteum of ovary
LipofuschinHeart, ganglion cells
Mallory bodiesLiver from alcoholic cirrhosis
Mast cellsGastro-intestinal tract, intermuscular tissue or skin
MelaninNegroid skin, naevus tumours
MitochondriaRenal tubules, liver and heart
MucinSmall intestine, submaxillary gland
MucopolysaccharidesSkin, umbilical cord
Muscle, striationsSkeletal muscle
MyelinCerebrum, cerebellum or spinal cord
Neurosecretory substanceHypothalmus
Neutral fatSubcutaneous tissue
Neutral mucinStomach
NisslBrain or spinal cord
NoradrenalineAdrenal medulla
6-nucleotidaseThyroid or liver
OsteoidBone in osteomalacia
Oxytalan fibresPeriodontal ligaments
Paneth cellsSmall intestine
PeroxidaseGranulocytes, erythrocytes
PhospholipidBrain or spinal cord
Plasma cellsRheumatoid synovitis, lymph nodes in plasmacytosis
Pneumocystis cariniiLung in diseased patient
Purkinje cellsCerebellum
Purkinje fibresHeart (subendocardium)
Reticulin fibresLiver, spleen, lymphoid tissue
Ribonucleic acidPlasma cell, neurones
RickettsiaeBrain of diseased patient
Russell bodiesRheumatoid synovitis
SeratoninSmall intestine (argentaffin cells)
Sialomucin (sialidaselabile)Salivary gland
Sialomucin (sialidaseresistant)Colon
SpirochaetesLyophilised T. Pallidum reconstituted, smeared on to clean glass slide and air dried.
SteroidsAdrenal cortex, seminiferous tubules
Sulphated mucinCartilage, colon
TryptophanPaneth cells, pancreas
Tubercle bacilliTissue from diseased patient, commonly lung
TyrosinaseSkin (melanocytes)
UratesGouty tophi
Viral inclusion bodySurface lesions of diseased patient (herpes). Lung of diseased patient (cytomegalovirus)


  1. Bancroft JD, Stevens HC. Manual of Histologic Techniques. Churchill Livingstone 1984
  2. Fischer RS, Petty CS. Forensic Pathology U.S. Department of Justice, Washington D.C. 1977
  3. Robbins SL, Angell M, Kumar V. Basic Pathology, W.B. Saunders. 1981
  4. Tedeschi CG, Eckert WG, Tedeschi LG. Forensic Medicine. W.B. Saunders. 1977
  5. Wheater PR, Burkitt Hg, Daniels VG. Functional Histology: A text and colour atlas. Churchill Livingstone. 1987
  6. Churukian CJ. Manual of the special stains laboratory. The Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York. 1993

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