T cells belong to a group of white blood cells known as lymphocytes and play a central role in cell-mediated immunity. They can be distinguished from other lymphocyte types, such as B cells and NK cells by the presence of a special receptor on their cell surface that is called the T cell receptor (TCR). The abbreviation "T", in T cell, stands for thymus since it is the principal organ for their development. Several different subsets of T cells (Cytotoxic T cells, Helper T cells, Memory T cells, Regulatory T cells, Natural Killer T cells) have been described, each with a distinct function.
ART2
- a T-cell differentiation marker expressed by the majority of mature peripheral T cells in the rat. PMID: 16195877
CD1a
- T cell surface antigen
CD1d
- natural killer T cell (NKT cell) marker.
CD2
- early T cell marker.
CD3
- a T cell marker. PMID: 10341315
CD4
- helper T cell marker. PMID: 10341315
- expressed on surface of T helper cells.
CD5
- a T cell marker, expressed on B cells from bovine leukemia virus-(BLV) infected sheep. PMID: 1697010
CD7
- the most sensitive and specific T-cell deletion marker that can be used for routine formalin-fixed paraffin-embedded biopsy specimens. PMID: 11511839
- a differentiation marker that identifies multiple CD8 T cell effector subsets. PMID: 12594257.
CD8
- cytotoxic T cell marker. PMID: 10341315
CD11b (Mac-1)
- a marker for CD8+ cytotoxic T cell activation and memory in virus infection. PMID: 1500720.
CD25 (interleukin 2 receptor alpha)
- T-cell activation marker. PMID: 14760073
CD38
- T cell activation marker. PMID: 12613520
CD45RO
- Memory subset of CD8+ T cell marker. PMID: 16325196
- expressed on activated T-cells. PMID: 9613989
CD72
- expression is not restricted to B lineage cells in mouse strains expressing the CD72(b) allele; instead, a population of T lineage cells in these mice also expresses CD72. PMID: 8995186
CD134 (OX40)
- T-cell activation marker. PMID: 14760073, PMID: 12786817
CD150
- T cell activation marker. PMID: 15135295
CRTAM
- one of the most highly expressed surface markers of activated human CD8 T cells and NKT cells. PMID: 16300832
FOXP3
- regulatory (suppressor) T cell marker.
- a selective marker for a subset of adult T-cell leukaemia/lymphoma. PMID: 16193085
FT2
- identifies the feline analog of the human T8/Leu-2, murine Ly-2 molecules expressed by cytotoxic/suppressor T cells. PMID: 3081644
GPCA
- a mouse T-cell marker distinct from Thy-1. PMID: 6970179
HLA-DR
- T cell activation marker. PMID: 8430217
HML-1
- an exquisite marker for intraepithelial T cells and primary intestinal and cutaneous T-cell lymphomas. PMID: 2316623
HT23A
- a T-cell marker in the horse. PMID: 3069011
Leu-22
- a useful marker for lymphoid cells, preferentially of T-cell origin. PMID: 2785753
Ly-2
- T cell lineage specific marker. PMID: 3886788
Ly-m22
- the only antigen besides I-J so far known to be restricted to suppressor T cells. PMID: 6187835
MICG
- a 225,000 molecular weight glycoprotein that is present in the plasma membrane of adult thymocytes and peripheral T cells, as well as in embryonic prothymocytes, but absent in granulocytes and B lymphocytes. PMID: 2428732
MRC OX 8
- labels all peripheral T cells that are unlabeled by the previously described W3/25 monoclonal antibody. PMID: 6967416
MRC OX-22
- distinguishes two sets of T helper cells that have different functions. PMID: 2440674
OX40
- a T cell activation marker that may mediate T-B cell interactions. PMID: 8228223
PD-1 (Programmed death-1)
- a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma. PMID: 16819321
RT6
- T-cell differentiation marker. PMID: 11220625, PMID: 7547715, PMID: 3263942
TCR (T cell receptor)
- a stable marker for specific T-cells. PMID: 11121557
Thy-1 (CD90)
- a small GPI-anchored protein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells. PMID: 15356100
TSA-2 (Thymic shared Ag-2)
- a cell surface marker associated with T cell differentiation and activation. PMID: 10227982